Zofran Zydis wafers belong to a group of medicines called antiemetics. Zofran Zydis wafers work by helping to stop the nausea (sick feeling) and vomiting which can occur after certain treatments. 'Wafer' used in the product name, is the word used for the special type of tablet which dissolves in a few seconds when placed on the tongue. It is easier to swallow than ordinary tablets.